Preheat the oven to 375 degrees Fahrenheit. Bring a pot of water to boiling and cook noodles according to the package instructions. When the shells are done cooking drain from the water and allow them to cool.
Heat a large skillet over medium heat and add in the onions, bell peppers, and mushrooms. Cook until slightly tender and add in the ground beef, breaking into pieces. When the beef is cooked through reduce the heat to low and add in ½ cup of milk, Cajun seasoning, garlic powder, onion powder, Italian Seasoning and salt/pepper to taste. Cook for an additional 3-5 minutes.
Spray a 9 x 13-inch baking dish with nonstick spray. Stuff the pasta shells with the ground beef mixture and add them to the baking dish. Spoon the remaining meat mixture around the noodles.
Sprinkle the mozzarella cheese on top, cover and bake for 20 minutes until the cheese is nice and melted.